Endocrine Abstracts

Introduction: Estradiol is an important parameter in the evaluation of female fertility. Moreover, the measurement estradiol is essential in determining the right moment for oocyte retrieval in modified natural cycle IVF (MNC-IVF). Estradiol is measured by an immunochemical method and a change between immunoassays usually comes with a change in reference values due to differences in antibodies used and the lack of harmonization. In our hospital we changed in 2014 from the Auto...

Introduction: Despite adequate treatment with LT4 monotherapy, many patients with primary hypothyroidism still report complaints, as this treatment can not exactly imitate the endogenous homeostasis. We examined whether the different domains of HR-QOL were affected by the existence of a thyroid disorder and use of LT4 substitution, and whether a lower ratio of free triiodothyronine (fT3)–free thyroxine (fT4)</sup...

Introduction: The Thr92Ala polymorphism of deiodinase 2 (DIO2) is associated with increased expression in the brain of genes associated with oxidative stress, and may predict favourable response to combination thyroxine (L-T4) plus triiodothyronine (T3) therapy. We examined whether the Thr92Ala polymorphism (rs225014) was associated with differences in thyroid hormone parameters, health-related quality of life (HR-QOL) and cognitive functio...